Posts Tagged ‘Stem Cell Worx’

Future Hip Implants Will Use Patient’s Own Stem Cells

Saturday, September 1st, 2012

Reported by Helen McArdle – Herald Scotland

SCOTS researchers have revealed plans to create a revolutionary new hip implant that will use the latest stem cell technology to allow patients to grow their own bone, removing the need for regular replacement surgery.

The prosthetic implants are being developed by scientists at Glasgow University in collaboration with orthopaedic surgeons at the city’s Southern General Hospital and they hope to have a prototype ready within 10 years.

The move follows a breakthrough last year by a team at the university’s Institute of Molecular, Cell and Systems Biology when they succeeded in creating a special plastic surface capable of controlling what stem cells become – a technique that was previously impossible.

The plastic is covered in tiny pits 120 nanometres across which, when stem cells are placed on the surface, encourages them to grow and spread across the pits in a way which ensures they differentiate into therapeutically useful cells.

While the implant itself will be made of an advanced polymer, already commonly used in spinal and other orthopaedic procedures, it will be coated for the first time in the university’s unique plastic. As a result, once inserted into a patient’s bone marrow – a rich source of mesenchymal stem cells – these can be made to divide and differentiate into fresh bone cells, creating a much stronger and more durable implant.

Dr Matthew Dalby, a specialist in bone tissue engineering at the institute, said: “By covering the implant in this surface, we can ensure the mesenchymal stem cells differentiate into the bone cells.

“This will help the implant site repair itself much more effectively than has ever been possible before and could well mean implants will last for the rest of patient’s life.

“People are living longer – long enough, in fact, that we’re outliving the usefulness of some of our body parts. Our new implant could be the solution to the expensive and painful follow-up surgeries which conventional implants require.”

Currently, implants are commonly made from materials such as polyethylene, stainless steel, titanium or ceramic and tend to require replacement every 15 to 20 years.

In hip replacement surgery, the head of the thigh bone is removed and replaced with an implant which is held in place by a rod fixed inside the marrow along the length of the bone.

When traditional implants are fixed into bone marrow, the marrow’s stem cells do not receive messages from the body to differentiate into bone cells.

Instead they usually differentiate into a build-up of soft tissue which, combined with the natural loss of bone density that occurs as people age, can weaken the bond between the implant and the body.

Safety concerns over metal hip implants were also raised earlier this year when it emerged thousands of Scots patients could be at risk from a build-up of toxic debris from DePuy ASR implants, which were first used on the NHS in 2003.

 

American Doctor Shows Age is No Barrier

Sunday, August 26th, 2012

Life Less Ordinary: Dr Walt Failor is right at home at Wairarapa Hospital.

At an age when many doctors are retiring to spend more time on the golf course, Walt Failor is just starting his new career in our home town, Masterton, New Zealand, and the Hospital where Maree worked for over 10 years.

The 63-year-old graduate doctor already has a lifetime of extraordinary experiences under his belt, and he’s now gone halfway round the world to work at Wairarapa Hospital, New Zealand.

American first-year house surgeon Dr Failor is working alongside colleagues younger than his own children and loving every minute of it.

“It’s amazing. I’m around talented people. When you have that opportunity you gain from it.”

Previously trained as a chiropractor, Dr Failor began his medical degree at the University of Health Sciences in Antigua when in his mid-50s.

In his third year of study, Dr Failor travelled around United States hospitals on training rotations, and through sheer persistence he procured a rotation at world famous Cook County Hospital in Chicago.

Determined to prove his competence, he volunteered for a six-week rotation at Cook County juvenile detention facility, performing HIV and STI checks on gang members and youth offenders.

His willing attitude earned him further work experience at the hospital.

He said on a trauma rotation he saw 27 gunshots in one night. “I’m more familiar with gunshots than a runny nose.”

But becoming a doctor is only part of his colourful career history. Dr Failor has been a reserve deputy sheriff, All-American footballer, pilot, commercial fisherman, chiropractor, hunter, shop worker and logging crew member.

He has clung to a tree for two days in Alaska while a brown bear circled the base, taken a childhood fishing trip with Senator Robert F Kennedy, and played on a college football team with O.J. Simpson.

He said at that time, University of Southern California Trojans teammate Simpson was “a great guy”. “It’s a dubious distinction now I realise but in college he had no peer. He’s the best player I’ve ever seen.”

Dr Failor was born in Aberdeen, Washington, where his father owned a sporting goods store but also became mayor of Aberdeen when his children were young.

In high school Dr Failor excelled at football and baseball, earning a place on the All-American football team and being drafted into the New York Yankees baseball team. However, his father decided he should go to college, so he didn’t tell him he had been drafted until years later.

After completing a degree in business and athletics, Dr Failor spent some time in Aberdeen working at his father’s store and patrolling beaches as a reserve deputy sheriff.

Deciding it was not his “cup of tea”, he left Aberdeen to train as a chiropractor in the American Midwest.

Upon his graduation in 1982 Dr Failor moved to Alaska to set up a practice and spent more than a decade there commercial fishing, dodging brown bears and flying Piper aircraft.

He arrived in Masterton in September 2011, fresh from driving a long-haul truck across the US to pay for his airfare to New Zealand.

Dr Failor said he chose New Zealand as a graduate job destination because he preferred the style of the entrance exams to that of other countries.

Before coming here, his only exposure to Kiwis was through 1972 All Black Duncan Hales who coached his chiropractic school rugby team to win the national championships in the 1970s.

He said Masterton reminded him of his home town Aberdeen for both its size and lifestyle. “Coming here is the best decision I made.”

Dr Failor would like to become a consultant in emergency medicine – a qualification he will reach by the time he is 68.