Archive for the ‘stem cell diabetes’ Category

How Sugar Damages Cells and Causes Diabetes

Sunday, December 18th, 2011

Problems associated with higher-than-desired sugar levels are myriad.  Most stem from the central problem of excess glucose flooding into blood vessel cells.

Everyone with glucose-handling difficulties is at increased risk of developing life-threathening conditions ranging from heart disease and stroke to blindness, nerve damage, depression, and kidney disease.  These dire complications are the result of hyperglycemia (excess glucose in the bloodstream).  There is now evidence that those with high “normal” fasting glucose levels suffer a greater incidence of disorders that are associated with diabetic conditions.

An increasing number of scientific studies reveal that sugar toxicity is a causative factor in a host of degenerative diseases and premature aging.  One only has to look at the multiple diseases suffered by diabetes to appreciate the lethal effects of protein glycation and carbonylation, major complications related to excess sugar (glucose) levels.  Non-diabetes also encourter destructive protein-damaging glycation and carbonylation processes, albeit at a lower rate than diabetes.

Taking steps to guard against glycation would appear to be a mandatory part of a health maintenance program.

Avoid food cooked at high temperatures to reduce the formation of AGEs (Advanced Glycation Ends) in the body.

[AGEs are the end-products of glycation reactions, in which a sugar molecule bonds to either a protein or lipid molecule without an enzyme to control the reaction].

In pre-diabetes, a patient’s blood glucose levels are abnormally evalated, but often not enough to warrant diagnosis of type II diabetes early on. Most pre-diabetic patients experience few if any symptoms, and thus have no idea that they are at risk of developing diabetes.  That is why it is so important to guard against sugar toxicity before a diabetic state manifests.  See the symptoms below.

There are good sugars and bad sugars.

Bad sugars, often referred to as simple sugars, are those in foods that do not offer any other nutritional benefit. Examples of simple sugars include foods like soda, sweets, sugar cereals, juice drinks, and refined grains.

Good sugars, or complex carbohydrates, are present in foods that provide nutrients such as vitamins, minerals, protein, and fibre. Examples of complex carbohydrates include foods like fruit, vegetables, beans, and whole grains.

Careful monitoring of your weight and your food choices will help you prevent diabetes.

Focus on lean proteins at each meal, and restrict your sugar and starch intake.  You also need to choose fibre-rich whole grains to release glucose in a steady stream to moderate blood sugar levels.  Good food choices include:

  • Dietary fibres
  • Eggs
  • Flaxseed oil
  • Lamb
  • Lean Beef
  • Low-fat Cottage Cheese
  • Nuts and Seeds (raw: almonds, sesame seeds, hazelnuts, cashews)
  • Poultry
  • Soy products
  • Cold-water fish
  • Veal
  • Yoghut

An accurate measurement of underlying glucose impairment is the hemoglobin A1C blood test.  But be on the look out for these symptoms:

  • Blurred vision
  • Excessive thirst
  • Extreme hunger
  • Increased urination
  • Increased fatigue
  • Irritability
  • Numbness/tingling in fingers and toes
  • Weakness or fatigue
  • Weight gain.

The key to living a long life unemcumbered by disease is to identify aging parts of your body that may be experiencing decline before disease strikes and take action immediately to treat them.  This can be accomplished by comprehensive annual check-ups that include advanced screening methods and thorough blood testing.

By taking action early, utilizing an integrative program of healthy diet, targeted nutrients, bioidentical hormones, and nutritional supplementation, you can ensure a bright healthy future free from silent diseases that rob aging adults of their helpful vigor.

 

Reference: Life Extension Special Edition Magazine

 

Stem Cell Spray Heals Burns

Sunday, November 28th, 2010

 

 
Stem Cell Spray Heals Burns 
 
November 26th, 2010 @ 11:25pm
By Ed Yeates.    Video Courtesy of KSL.com

SALT LAKE CITY — A spray solution of a patient’s own stem cells is healing their severe burns. So far, early experiments under a University of Utah pilot project are showing some remarkable results.

What was once a serious burn on Kaye Adkins foot is healing nicely now because of a topical spray. With diabetes as a complication, the small but open wound had not healed after weeks of failed treatments.

Dr. Amalia Cochran with the university’s Burn Care Center says, “With a wound that is open for several months, as this patient suffered prior to seeing us in our burn clinic, we worry about a pretty heavy bacterial load there.”

But enter the evolutionary world of regenerative medicine, using almost a bedside stem cell technique that takes only about 15 minutes. With red cells removed, a concentrate of platelets and progenitor cells is combined with calcium and thrombin. The final mixture looks almost like Jello.

“I woke up and saw them with this big thin, looked like a needle, and I said you’re going to put that in my foot? And they said NO, we’re going to spray,” Adkins said.

Though her own skin graft had failed before, the topical spray was used during a second graft. It “took” and healed. “I had never heard of anything like that. It was just amazing,” Adkins said.

Adkins burn is healing and so is her heart. Coincidentally, stem cells were used during her bypass surgery five weeks ago to hasten healing for that procedure as well. While hundreds of heart patients have had stem cell treatments, burn patients are still few in numbers.

Cardiothoracic surgeon Amit Patel and burn care surgeon Amalia Cochran are experimenting on small burns for now. But down the road, both are hoping for large scale clinical trials on patients with much larger burns.

Patel asks, “Can we accelerate healing or improve healing. Then it’s the quality of healing. And then, we hopefully advance to decreasing the scarring process completely.”

“It’s my hope that in my career,” Cochran adds, “stem cells will completely revolutionize how we’re able to take care of patients. Not just with small burns that are challenging to heal, but with massive burn injuries as well.”

The military is keeping a close eye on the Utah project. The future for treating burns on soldiers could stagger the imagination even more. Patel says “regrowing your own skin in a bioreactor is very realistic and that’s not five years away even. We start with a biological band aid and hope to end up with basically synthetic skin that’s still derived from your own cells.”

In this dream of regenerative medicine, Patel believes we can only imagine a day when sheets of pristine skin might be available to any patient off the shelf.