The health benefits of resveratrol are widely reported.  Scientific studies in laboratories around the globe attribute cancer-fighting, anti-aging, anti-oxidant, anti-inflammatory and cardiovascular advantages to resveratrol.

In humans, however these benefits have only been demonstrated with the use of pure resveratrol directly on the cell and blood.

Studies have found out that resveratrol pills taken orally are quickly digested and metabolized in the intestines and liver, and less than 5 percent of the oral dose in pill form remains in blood plasma as free resveratrol.  This metabolic process is known as the “first pass effect,” and results in the compound being eliminated from the digestive and urinary system right after its ingestion.  Consequently, even if large dosages of resveratrol are consumed in pill form, its concentration levels inside the blood fail to reach the required levels necessary for testing conditions within the laboratory.

Intraoral Resveratrol Overcomes “First Pass Effect”

However, scientists have found that buccal delivery (also known as intraoral) is the most efficient method of administering resveratrol.  When absorbed through the inside of the mouth without swallowing, the progressively released resveratrol component may be absorbed by intraoral mucosal tissues and pass into the systemic circulation directly.  Studies have found out that buccal delivery (i.e. intraoral delivery) brings up to 250 times more unchanged resveratrol found in plasma compared to when drawn in pill form.  This efficient form of resveratrol ingestion can be achieved through melts, sub-lingual tablets, lozenges, liquids and intraoral sprays.  In particular the intraoral delivery avoids the first pass effect.

The German article along with the actual study states that not many products can be found in these forms.  Even though some manufactures have added compounds in pills to enhance their absorption levels, this does not resolve the “first pass effect” issue.

Stem Cell Worx is one of the few health supplements that is taken intraorally and it contains a 98%-99% pure, trans resveratrol that comes from Japanese knotweed as well as other important ingredients that support a number of health benefits including natural activation of one’s own adult stem cells and strengthening of the immune system.

References:
http://muurahaiset.net/wiki/index.php/K%C3%A4ytt%C3%A4j%C3%A4:GuiPeebles961