Archive for the ‘stem cell transplant’ Category

Stem Cell Match Found But Now Hannah Too Weak for Transplant

Thursday, February 6th, 2014

Hannah Day

Hannah Day lives in Victoria, Canada and has been in and out of hospital for most of her short life. Hannah is four years old and is battling leukemia.

The Day family went public just after Christmas to try and find a stem-cell donor for Hannah. Thousands of people rallied, submitting cheek swabs to OneMatch, a stem-cell and marrow registry run by Canadian Blood Services in the hope of finding a suitable donor. The odds of finding a match were estimated as being one in a million.  The response was tremendous, with 40,000 people signing up as potential donors in just 48 hours.

After several weeks, Mom Brooke Ervin received good news on Monday: A match has been found. In fact, more than one.

But there was a heartbreaking twist.

“Matches were found, but now it won’t happen. Not for Hannah,” said Ervin from B.C. Children’s Hospital.

Doctors say the little girl has gone through too much radiation to successfully have a stem-cell transplant.

Doctors report Hannah’s body was exposed to so much radiation from her first cancer in 2012, a rare type called rhabdomyosarcoma, that she cannot now withstand a full stem-cell transplant, that would provide a promising chance of putting her cancer into remission.

The options now available to Hannah are Palliative care or, a rare, high-risk transplant called the Hail Mary procedure, that can be carried out next month that carries a 60 per cent chance of success.

“I bawled. I cried so hard. I can’t believe these are the choices we have after everyone’s hard work,” said the devastated mom. “I want everyone to know how thankful we are to see so many people try to save her life,” says Mom, Brooke Ervin.  “It was successful and matches were found, but now it will not work. It is all on my shoulders now.”

The Hail Mary procedure, called a haplo-identical transplant, requires stem cells from Ervin. She is only a half-match, but doctors say because her stem cells once helped protect Hannah as a baby, they may also have a chance of killing off the remaining leukemia cells in Hannah’s body.

In an Ontario case in 2010, the haplo transplant was still considered an experimental procedure and had to be performed overseas. It remains rare. Hannah’s oncologist has only performed the procedure twice, said Ervin. She hasn’t yet asked if those treatments were successful.

“It was a horrible decision no family should have to make”, said Ervin, but for them there can only be one choice.

Canada currently has 326,000 people who are already registered as potential stem-cell donors. Hannah is one of 750 Canadians who are currently awaiting a stem-cell transplant.

To become a stem-cell donor you can fill out a questionnaire online if you’re between the ages of 17 and 35, and you’ll be sent a kit in the mail. A swab of your cheeks will reveal if you’re a suitable donor. Once identified as a match, donors will undergo one of two procedures. Stem cells can be harvested from bone marrow under general anesthetic, or through peripheral blood stem cell donation.

Source:     http://globalnews.ca/news

Daniel Paid It Forward with Stem Cells

Sunday, January 19th, 2014
Daniel Lilburne (Left) with brother Ryan (Right)

Daniel Lilburne (Left) with brother Ryan (Right)

In a remarkable domino effect, Daniel Lilburne has repaid a debt to France for stem cells that saved the life of his younger brother Ryan more than five years ago.

The 23-year-old has donated his stem cells so a young French woman could have a bone marrow transplant – the same operation Ryan had in 2008 using stem cells from the umbilical cord of a newborn in France.

Ryan was 15 and battling a serious blood disorder and leukaemia when Perth doctors started scouring an international bone marrow registry for a suitable tissue match to provide stem cells for a transplant.

They initially screened the most likely potential donors – his parents Natalie and Bruce and 17-year-old Daniel – but none matched.

When they failed to find a donor after a worldwide search, doctors decided to go ahead with the second-best option, using stem cells from the umbilical cord of a baby boy in France.

After massive chemotherapy to kill off his diseased bone marrow, Ryan was given the cord blood stem cells and has since made a full recovery, with more than 100 family and friends planning to celebrate his clean bill of health at his 21st birthday party tonight.

But last January, more than four years after Ryan’s transplant, Mrs Lilburne was contacted by the registry with news that stunned her.

Daniel had been identified as the best match in the world for a young woman who needed a bone marrow transplant – and she happened to live in France.

“They told me I wouldn’t believe – that Daniel was the best match for this girl – and at first I just kept saying ‘you’re joking’ because I couldn’t believe the chances of that happening,” Mrs Lilburne said.

“If Ryan hadn’t been sick, Daniel would never have been on the registry, so I like to think we’ve helped pay back the generosity of the French family who donated their baby’s cord blood.”

In August, Daniel donated the stem cells, which required twice-daily injections for four days before and left him with aching bones.

“When I heard about the injections I thought ‘hang on, what have I got myself in for’ but it wasn’t painful and really being able to help a girl in France was pretty awesome,” he said.

Just before Christmas, the Lilburnes’ learnt the 26-year-old woman was out of hospital and doing well.

People aged 18 to 45 in good health can join the Australian Bone Marrow Donor Registry. Details are at abmdr.org.au or contact the Australian Red Cross Blood Service on 13 14 95 Australia.

Source:   The West Australia