Archive for the ‘adult stem cells’ Category

Boy Makes Full Recovery From Rare Blood Disorder

Monday, December 27th, 2010

26 December 2010 – As reported in BBC News, UK

Jack Hayhoe    Jack Hayhoe

This article highlights the importance of the Bone Marrow

Wirral mother wants to thank the donor of the bone marrow that she said “saved her son’s life”.

Two years ago, Mandy Hayhoe, 34, did not think she would see her son playing with his Christmas presents like any other happy child.

Her son Jack has Wiskott-Aldrich syndrome, a condition in which he does not produce enough blood platelets.

Now, after a bone marrow transplant and months of specialised after care, Jack is like any other two-year-old.

“I can’t thank the person who donated their bone marrow enough for the new life it has given Jack.

“He has spent much of his life in and out of hospital having blood transfusions and operations, but now he is doing really, really well,” Mrs Hayhoe said.

Before the operation the toddler had just three blood platelets – when he needed between 150 and 450. Without the transplant he may not have lived beyond the age of 10.

Blood platelet shortageWiskott-Aldrich syndrome affects only one in four million people. Their blood may not clot easily, they will be prone to catching severe infections, and will need frequent blood transfusions.

The only hope of a cure is through a bone marrow transplant or by stem cell transplantation from umbilical cord blood that has been banked from baby donors.

Fortunately for the Hayhoe family, who are from Hoylake, within seven months of being on the donor list matching bone marrow was found.

“We couldn’t believe it,” Mrs Hayhoe said, “Some people are on the waiting list for years and some don’t even find a match.

Jack Hayhoe When little Jack was in and out of hospital having transfusions

“We were lucky enough to be offered two. He had the operation back in July last year and it was a success.”

Now Jack is producing 100% donor cells – which means his body is working normally.

Before he had the operation, he had to rely on others donating blood platelets – at a time when there was a shortage.

Back in early 2009, the Hayhoes campaigned to highlight the need for blood platelets. Donors can give their blood platelets as easily as giving blood.

Now they do not have to worry.

“He has been so excited for Christmas Day,” his mother said, “He has spent the past couple of weeks looking out of the window waiting for Father Christmas.”

In January he will be back in hospital, and hopefully, she said, they will be told to come back for an appointment only once a year instead of the routine check-ups.

Stem Cell Spray Heals Burns

Sunday, November 28th, 2010

 

 
Stem Cell Spray Heals Burns 
 
November 26th, 2010 @ 11:25pm
By Ed Yeates.    Video Courtesy of KSL.com

SALT LAKE CITY — A spray solution of a patient’s own stem cells is healing their severe burns. So far, early experiments under a University of Utah pilot project are showing some remarkable results.

What was once a serious burn on Kaye Adkins foot is healing nicely now because of a topical spray. With diabetes as a complication, the small but open wound had not healed after weeks of failed treatments.

Dr. Amalia Cochran with the university’s Burn Care Center says, “With a wound that is open for several months, as this patient suffered prior to seeing us in our burn clinic, we worry about a pretty heavy bacterial load there.”

But enter the evolutionary world of regenerative medicine, using almost a bedside stem cell technique that takes only about 15 minutes. With red cells removed, a concentrate of platelets and progenitor cells is combined with calcium and thrombin. The final mixture looks almost like Jello.

“I woke up and saw them with this big thin, looked like a needle, and I said you’re going to put that in my foot? And they said NO, we’re going to spray,” Adkins said.

Though her own skin graft had failed before, the topical spray was used during a second graft. It “took” and healed. “I had never heard of anything like that. It was just amazing,” Adkins said.

Adkins burn is healing and so is her heart. Coincidentally, stem cells were used during her bypass surgery five weeks ago to hasten healing for that procedure as well. While hundreds of heart patients have had stem cell treatments, burn patients are still few in numbers.

Cardiothoracic surgeon Amit Patel and burn care surgeon Amalia Cochran are experimenting on small burns for now. But down the road, both are hoping for large scale clinical trials on patients with much larger burns.

Patel asks, “Can we accelerate healing or improve healing. Then it’s the quality of healing. And then, we hopefully advance to decreasing the scarring process completely.”

“It’s my hope that in my career,” Cochran adds, “stem cells will completely revolutionize how we’re able to take care of patients. Not just with small burns that are challenging to heal, but with massive burn injuries as well.”

The military is keeping a close eye on the Utah project. The future for treating burns on soldiers could stagger the imagination even more. Patel says “regrowing your own skin in a bioreactor is very realistic and that’s not five years away even. We start with a biological band aid and hope to end up with basically synthetic skin that’s still derived from your own cells.”

In this dream of regenerative medicine, Patel believes we can only imagine a day when sheets of pristine skin might be available to any patient off the shelf.