Archive for the ‘activate stem cells’ Category

Toddler Given Life-Saving Windpipe Transplant Using Her Stem Cells

Friday, May 3rd, 2013
As reported in The Telegraph

 

Hannah receives a visit from her parents at the Children's Hospital of Illinois in Peoria after receiving a new windpipe using her own adult stem cells.

Hannah receives a visit from her parents at the Children’s Hospital of Illinois in Peoria after receiving a new windpipe using her own adult stem cells.

A South Korean-Canadian toddler has been given a life-saving windpipe transplant made from plastic fibres and some of her own stem cells.

Hannah Warren, aged two, was born without a trachea and is now the youngest person to ever receive a bio-engineered organ, after an operation in the United States.

She had spent her life in an intensive care unit in Seoul, with a feeding tube keeping her alive. Doctors had initially given Hannah little chance of surviving.

The nine-hour transplant was a life-saving surgery for the child, who was unable to breathe, speak, swallow, eat or drink on her own since birth.

Because the procedure used stem cells from her own bone marrow rather than a donor organ, her immune system is unlikely to reject the transplant. Doctors said she could return home and lead a normal life within months.

“The most amazing thing, which for this little girl is a miracle, is that this transplant has not only saved her life, but it will eventually enable her to eat, drink and swallow, even talk, just like any other normal child,” said lead surgeon Paolo Macchiarini of the Karolinska Institute in Stockholm.

“She will go from being a virtual prisoner in a hospital bed to running around and playing with her sister and enjoying a normal life, which is a beautiful thing.”

Scientists hope the stem cell-based therapy will diminish reliance on human organ donors and the associated risks of immune system suppression.

“We are crossing frontiers with these transplants,” Macchiarini said in a statement.

 

 

Adult Stem Cells – Clinical Trials for ALS

Tuesday, April 23rd, 2013

Clinical trials using adult stem cells continue for those who have ALS Disease.

Amyotrophic lateral sclerosis (ALS), often referred to as “Lou Gehrig’s Disease,” is a progressive neuro-degenerative disease that affects nerve cells in the brain and the spinal cord.

20,000-30,000 people in the United States have ALS, and an estimated 5,000 people in the United States are diagnosed with the disease each year. ALS is one of the most common neuromuscular diseases worldwide, and people of all races and ethnic backgrounds are affected. ALS is 60% more common in men than women, primarily affecting those males between the ages of 35 and 65.

Patients who took part in the first clinical trial will receive a second implantation to the cervical, or upper, region of the spine – where the nerves that control breathing reside. Most ALS patients die of respiratory failure as these nerves die or are damaged by the disease.

“We believe that the cells and the route of administration are safe,” says Feldman, who is the principal investigator of the trial and the director of the U-M’s A. Alfred Taubman Medical Research Institute, U.S.A.  “The FDA go-ahead to bring these patients back for re-dosing is a further validation of that.” The trial is funded by Neuralstem, to which Dr. Feldman is an unpaid consultant.

Click video below.

Further details are available at: http://usatoday30.usatoday.com/news/health/story/2012-08-05/clinical-trial-fights-ALS/56791326/1