Author Archive

Lung Disease Sufferers Explore Stem Cell Therapies as Alternative to Lung Transplant

Tuesday, November 5th, 2013

New Lungs

Regenerative medicine is the latest medical technology for the restoration and repair of damaged lung tissue caused by lung disease. As the leaders in lung treatment, Lung Institute’s physicians have harnessed this advancement in modern medicine to bring patients suffering with conditions like chronic obstructive pulmonary disease (COPD), emphysema, chronic bronchitis, and pulmonary fibrosis an innovative treatment choice that betters their quality of life and helps them to breathe easier.

Often, many of these patients have been told that lung transplantation is their only option, and as a result many are turning to advanced treatments such as pulmonary stem cell therapies to enhance lung function and regenerate healthy lung tissue.

Stem Cell Therapy vs. Lung Transplant for Lung Disease

Chronic obstructive pulmonary disease (COPD) is the third leading cause of morbidity and mortality in the United States, and a top five cause of death worldwide. Although there are many suppressive treatments available to COPD sufferers, the progressive nature of this disease almost unavoidably leads to a diminished quality of life.

Often, once most types of conventional treatment methods are exhausted, COPD sufferers are told that their treatment path is going to result in a lung transplant. Before undergoing this invasive, and sometimes risky, surgery it is important to know the outcomes of a lung transplant.

The excerpt below, from the National Institutes of Health (NIH), outlines the life expectancy of an individual post lung transplant surgery.

“In recent years, short-term survival after lung transplant has improved. Recent data on single-lung transplants show that:

  •     About 78 percent of patients survive the first year
  •     About 63 percent of patients survive 3 years
  •     About 51 percent of patients survive 5 years

Survival rates for double-lung transplants are slightly better. Recent data shows that the median survival for single-lung recipients is 4.6 years. The median survival for double-lung recipients is 6.6 years.

As you can see, the median number of years added to a person’s life post lung transplant ranges from 4.6 years to 6.6 years depending on the type of surgery received. This procedure can improve quality of life, but there is also risk of complications including infection, rejection of the new lung(s), and in some cases, an increased chance of developing diabetes, kidney damage, and osteoporosis.

Regenerative therapies are emerging as an alternative and preemptive treatment, to the invasive option of lung transplantation.

How do stem cells restore damaged lung tissue?

Lung Institute utilizes autologous stem cells, meaning those derived from the patient’s own blood or fat tissue, for treatment. These somatic, or adult stem cells have the unique ability to self-renew and replicate, and are capable of forming any type of tissue found in the human body, including lung tissue.

What is the stem cell treatment process like?

This minimally invasive, outpatient procedure is performed over the course of three days within the Lung Institute’s Office located in downtown Tampa, FL. For pulmonary conditions, the stem cells are stimulated to increase in number by oral and injectable agents. Next, the stem cells are derived from the patient’s own blood or bone marrow and are given back to the patient intravenously.

In conclusion: Stem Cell Therapy vs. Lung Transplant for Lung Disease

Both stem cell therapies and lung transplantation have been proven, in many cases, to improve sufferer’s quality of life. However, lung transplantation is an invasive, inpatient surgery that can have risky complications and a longer recovery time.

Stem cell therapies do not replace the need for a lung transplant, but can slow the progression of lung disease, and therefore prolong the need for a transplant. Stem cells and other forms of regenerative therapies are also proven to significantly improve sufferer’s quality of life.

A recent Lung Institute patient, Peter Pike, was diagnosed with COPD and underwent stem cell therapies with at our clinic in Tampa a little over 5 months ago. He is now able to perform everyday functions without feeling out of breath; even his wife says his overall disposition has improved. To learn more about how Pike’s life has improved, watch his testimonial video by clicking here.

Reference: http://www.digitaljournal.com/pr/1560123

Dr Noel’s Only Wish Is To See His Baby Daughter

Sunday, October 27th, 2013

Jared and Hannah Noel NZ Herald Jared Noel has just one wish before he dies following a five-year battle with cancer: to see his yet-to-be-born daughter.

“My greatest hope is that I get to spend some time with her and enjoy fatherhood. She won’t know me. She won’t remember me. But I’d like to let her know how much I would have wanted to be there when she’s 18, when she’s 25,” he said.

Dr Noel, 32, a physician at Auckland City Hospital, New Zealand was diagnosed with bowel cancer in November 2008. He has since battled through 66 rounds of chemotherapy and two major operations. Despite knowing the cancer would eventually beat him, he and his wife, Hannah, decided to try for a baby in the hope that he would live long enough to experience the first part of his child’s life. After four rounds of IVF, they succeeded, and their daughter is due on January 21. But last week, the couple were given the devastating news that the cancer had grown rampantly in Dr Noel’s liver and spread to his lung.

Without more chemo, it was unlikely he would live past Christmas. “This is the moment we have been dreading for five years and have been lucky to escape until now,” Dr Noel wrote on his blog on Saturday after receiving the diagnosis. “This is where everything changes. I have a lifespan measured in months. “The disappointment is compounded by knowing we have a daughter waiting to meet us, and for the first time, doubt has been cast over whether or not I will make that meeting. This is aggressive cancer, doing its best to kill me, to rob our child of their father.”

The couple did not have the money to pay for the drug Avastin, which it’s hoped will slow the growth of the tumours enough to extend Dr Noel’s life expectancy beyond the birth of his daughter – though it will not cure him. Ten courses of the medicine, which is not funded by Pharmac, cost $60,000.

Dr Noel said he had always been “a little reluctant to pay for a drug that does not change outcome”. But in light of his imminent fatherhood, he said, his life expectancy had become more important and he was open to fundraising for the Avastin.

“If it wasn’t for her [the baby], we would do our best and let nature take its course. But all of a sudden months and weeks are the difference between meeting my daughter or not and maybe the difference between me having a few months with her or not. It means a lot to Hannah, as she’ll get to see me holding her. I’m doing it mainly for Hannah and my daughter now.”

As a result they allowed a friend to set up a page on fundraising site Givealittle appealing for the $60,000. The page went live last week and within seven hours it had raised the money. Within days the fund has reached $158,000. Many of the donations came from anonymous donors or people who did not know the Noels.

One woman has offered to give Dr. Noel her own Avastin injections, which she receives every two months.  The 67-year-old, who lives in Glen Eden, Auckland is starting to lose her eyesight and while the injections are not a cure, they are helping to slow the process. “It’s fully funded and I have no idea why this young man can’t get Avastin injections for his much worse problem. But I am absolutely prepared to give up my Avastin injections. I’m losing my sight. But I don’t care about that. This boy needs to be given some time. It’s just sensible. I’m 67 years old, why do I need them?  This is a young boy with a family coming.

A Givealittle spokeswoman said it was the quickest a fundraising target had been reached since the site was set up in December 2008.

Dr Noel said he was overwhelmed by the generosity shown. “I have no words. We’re just stunned. We’re grateful and humbled by it all. It’s just so overwhelming. I knew there was some support and empathy out there but the response that we’ve got – I have no words.” He said the extra money raised would go towards giving his wife financial security after he is gone. However, if it continued to come in at the present rate, he would consider setting up a trust to benefit his daughter.

Dr Noel said he planned to have his first course of Avastin and restart chemotherapy next week. He vowed to give his all to make sure he was there for the birth of his daughter.

“I’m at the business end of the fight now. But I’ve outlived everybody’s expectations so far. I can make it.”

Source: NZ Herald.