Archive for July, 2013

Early Liver Creation from Human Stem Cells

Saturday, July 6th, 2013

Scientists of the Yokohama City University Graduate School of Medicine have been responsible for mixing a cocktail of induced stem cells made from adult tissue in an attempt to grow buds of human liver.

Demand for organ transplant outpaces the number of donors, with more than 118,000 Americans waiting for a life-saving transplant, according to the U.S. Department of Health and Human Services. An average of 18 people die each day waiting for an organ transplant. Stem cells, which can grow into any other type of cell, have long held the promise of bridging this gap.

“The study holds out real promise for a viable alternative approach to human organ transplants,” said Matthew Smalley, a senior lecturer at Cardiff University’s European Cancer Stem Cell Research Institute who wasn’t involved in the study.

Elizabeth Lopatto, a reporter from Bloomberg said “the buds did not function as human livers but nonetheless demonstrated what may be considered the first few steps to creating new organs for transplants”.

The entire study underwent rigorous testing where liver cells were mixed with other types of human cells, including those from umbilical cords.

Reference: http://www.bloomberg.com

Stem Cell Transplants Clear HIV From Two US Patients

Friday, July 5th, 2013

Two cancer patients in Boston who were also infected with Human Immunodeficiency Virus (HIV) have no trace of the virus after receiving stem-cell transplants, suggesting they may have been cured of the Acquired Immuno Deficiency Syndrome(AIDS) causing infection.

The two patients, treated at Brigham and Women’s Hospital in Boston, stopped HIV treatment after the transplants, which in other patients has opened the door for the virus to come roaring back. In one patient there was no sign of the virus 15 weeks after stopping treatment, while the other has gone seven weeks without HIV rebounding, according to results presented today at the International AIDS Society’s meeting in Kuala Lumpur.

The researchers led by Timothy Henrich of Harvard Medical School and Brigham and Women’s Hospital said it’s too early to conclude the two men have been cured and the virus may be lingering in their brains or gut. Still, their cases are similar to that of Timothy Brown, the so-called Berlin patient, who was the first person to be cured of HIV after getting a bone marrow transplant for leukemia in 2007.

While stem-cell transplantation is not a viable option for people with HIV on a broad scale because of its costs and complexity, these new cases could lead us to new approaches to treating, and ultimately even eradicating, HIV, Kevin Robert Frost, the chief executive officer of amfAR, The Foundation for AIDS Research, which funded the study, said in a statement.

Researcher Timothy Henrich

Researcher Timothy Henrich

Read more at: http://www.livemint.com