Posts Tagged ‘stem cell supplements’

Robin Roberts Bone Marrow Transplant – Its All About Adult Stem Cells

Saturday, September 22nd, 2012

Robin Roberts, center, poses with her sister Sally-Ann Roberts, and Dr. Gail Roboz on the “Good Morning America” show August 30.

Robin Roberts, the popular “Good Morning America” co-anchor, underwent a bone marrow transplant Thursday to treat myelodysplastic syndrome. MDS is a rare disorder that had damaged her bone marrow, making it no longer able to make the healthy cells and platelets we all need to live. Her older sister, Sally-Ann, was Robin’s bone marrow donor.

In the procedure, a patient’s damaged bone marrow is eradicated and then replaced with healthy, donated marrow.

Although the words were not used, in fact, the transplant is another example of the successful, even routine use of adult stem cells.

“We always call it a bone marrow transplant, but really it is a transplant with blood stem cells,” said hematologist-oncologist Colleen Delaney, director of the program in cord blood transplant and research at Fred Hutchinson Cancer Research Center in Seattle.

If the full ramifications of the stories about Roberts were more widely known, it would be a real eye-opener. For example, as noted below, another terrific source is umbilical cord blood.

Obviously there is a better chance of success the closer the match between donor and recipient cells. Ms. Roberts was especially fortunate because her sister was an excellent match. (Finding a family match happens only about 30% of the time, according to USA Today’s story.)

“The other 70% (more than 10,000 patients each year) have to turn to an unrelated adult donor or donated umbilical cord blood,” wrote Michelle Healy. “Often treated as waste and discarded, umbilical cords and placentas are rich with blood-forming cells, and more recent studies show the outcomes of cord blood transplants ‘are just as good as conventional donor outcomes,’ Delaney said.”

And “Because cord blood transplants don’t require the close genetic matching needed for more conventional bone marrow transplants, they hold special promise for the thousands of patients each year who can’t find a well-matched, unrelated donor, a particular challenge for people of mixed ethnicity and minority backgrounds, says Delaney.”

NRL News Today asked Dr. David Prentice, an expert on the issue of stem cells, to comment. He said,

“An adult stem cell transplant is currently one of the most effective treatments for MDS, the condition that Robin Roberts has. No doubt, it’s a harrowing experience for MDS patients leading up to the transplant, with chemotherapy to destroy the cancer in her body. But then the adult stem cell transplant is a short and simple procedure—an IV injection into her vein, and the millions of adult stem cells begin looking for a new home.

“In this case, they will look to make themselves at home as new bone marrow, and begin producing new red blood cells to carry oxygen, white blood cells for immunity, and platelets for clotting.”

His conclusion cut to the chase:

“The more we focus on adult stem cells, the sooner we’ll find gentler and more efficient methods for transplants like this one, for other types of cancers, for anemias, as well as spinal cord injury, heart damage, and dozens of other conditions. Adult stem cells are truly the patient’s best friend.”

Published by the National Right to Life News Today.  Website: http://www.nationalrighttolifenews.org/news/2012

Future Hip Implants Will Use Patient’s Own Stem Cells

Saturday, September 1st, 2012

Reported by Helen McArdle – Herald Scotland

SCOTS researchers have revealed plans to create a revolutionary new hip implant that will use the latest stem cell technology to allow patients to grow their own bone, removing the need for regular replacement surgery.

The prosthetic implants are being developed by scientists at Glasgow University in collaboration with orthopaedic surgeons at the city’s Southern General Hospital and they hope to have a prototype ready within 10 years.

The move follows a breakthrough last year by a team at the university’s Institute of Molecular, Cell and Systems Biology when they succeeded in creating a special plastic surface capable of controlling what stem cells become – a technique that was previously impossible.

The plastic is covered in tiny pits 120 nanometres across which, when stem cells are placed on the surface, encourages them to grow and spread across the pits in a way which ensures they differentiate into therapeutically useful cells.

While the implant itself will be made of an advanced polymer, already commonly used in spinal and other orthopaedic procedures, it will be coated for the first time in the university’s unique plastic. As a result, once inserted into a patient’s bone marrow – a rich source of mesenchymal stem cells – these can be made to divide and differentiate into fresh bone cells, creating a much stronger and more durable implant.

Dr Matthew Dalby, a specialist in bone tissue engineering at the institute, said: “By covering the implant in this surface, we can ensure the mesenchymal stem cells differentiate into the bone cells.

“This will help the implant site repair itself much more effectively than has ever been possible before and could well mean implants will last for the rest of patient’s life.

“People are living longer – long enough, in fact, that we’re outliving the usefulness of some of our body parts. Our new implant could be the solution to the expensive and painful follow-up surgeries which conventional implants require.”

Currently, implants are commonly made from materials such as polyethylene, stainless steel, titanium or ceramic and tend to require replacement every 15 to 20 years.

In hip replacement surgery, the head of the thigh bone is removed and replaced with an implant which is held in place by a rod fixed inside the marrow along the length of the bone.

When traditional implants are fixed into bone marrow, the marrow’s stem cells do not receive messages from the body to differentiate into bone cells.

Instead they usually differentiate into a build-up of soft tissue which, combined with the natural loss of bone density that occurs as people age, can weaken the bond between the implant and the body.

Safety concerns over metal hip implants were also raised earlier this year when it emerged thousands of Scots patients could be at risk from a build-up of toxic debris from DePuy ASR implants, which were first used on the NHS in 2003.