Posts Tagged ‘bone marrow stem cells’

From the U.K. to the U.S.A. With Love. A Life Saved After 3% Chance Of Survival Given

Wednesday, October 12th, 2022
Alex Christopher and Patrick Languzzi

Alex Christopher’s donation of stem cells from the U.K. saved the life of Patrick Languzzi (in Boston, U.S.A.) who was given just a 3 per cent chance of survival after being diagnosed with a rare form of cancer.

A stem cell donor says he feels like he’s won the lottery after meeting the man whose life he saved. Alex Christopher’s donation saved the life of Patrick Languzzi who was given just a 3 per cent chance of survival.

Alex, from Chorley, Lancashire joined the stem cell register and had a bone marrow donation on a whim. He had no idea he had saved someone’s life on the other side of the world until months after Patrick’s operation.

The outlook for Patrick was bleak after he was diagnosed with a rare cancer called acute myeloid leukemia. The 56-year-old needed a bone stem cell match to have any chance of survival and then came a match from Alex in the U.K.

Alex, 35, told the Express: “Previous to this, I had never had an operation or even given blood. I first signed up after a colleague at work had blood cancer, so it inspired me.

“The risks were so small, mainly because of the advancement in medical science. It was a hassle-free process and I saved a life.”

Alex having his stem cell extraction
Alex having his stem cell extraction
Alex and Patrick meeting for the first time
Alex and Patrick meeting for the first time

Stem cell donors can choose to have their details passed on to potential recipients six months after the transplants. Alex decided he would do this and received an email from Patrick thanking him for saving his life.

The email eventually led to Patrick travelling more than 3,000 miles from his home in Boston, Massachusetts, U.S.A. to meet up with Alex in May. Father-of-one Patrick said the first thing he did when he came face-to-face with Alex was to tell him he loved him.

“It was pretty emotional,” he said. “It was just really great to meet him.”

He continued: “I had to pinch myself because how many people have that opportunity? I survived and actually got to meet the person who helped me do that.

“We call each other brothers now and that’s what it’s like, as if we are family. I only had one match so it was unbelievable.

“When I got diagnosed, I said to my wife ‘I just want to live long enough to see our son graduate’ and luckily I did. It happened in June 2022 and it was so emotional.

“It has absolutely saved my life. My outlook was pretty bleak before the procedure.”

Alex, who is also a father after just welcoming a baby daughter, said he was prompted to donate stem cells when his boss and friend, Peter McCleave, was diagnosed with myeloma in 2018. He was not a match for Peter, but within six months he matched with Patrick.

Alex added: “I saved Patrick’s life and it was like winning the lottery but I didn’t even need to pay for a ticket. I would do it again if I could without a doubt.

“I was not aware really of stem cell donation and, even when I was, I didn’t realize how important it would be to someone’s life. It hasn’t dawned on me quite what I’ve done.

“It just seemed at the time a simple thing to do, an act that would help someone somewhere. It is difficult to gauge the impact I suppose but ultimately it can have such a massive impact on someone’s life.”

Patrick’s first email to Alex arrived in his inbox just days before Christmas. It read: “Hello, you saved my life. Thank you.”

Remembering how it felt when he read it, Alex said: “It broke me. I cried at the email and it only then started to feel real for me.

“I then was aware of the impact it had on his life. He has been able to attend his son’s graduation.

“You don’t know anything about the recipient until six months after the procedure, and only if you agree to your details being shared and vice versa. In my instance, I agreed to give my details and I was, I suppose, excited about that. I was excited but wanted to respect Patrick’s privacy too.

“Patrick was at death’s door. He was given a 3 per cent chance of survival.”

Patrick said his goal now is to help others by raising awareness of stem cell donation. He said: “It really changed my life because I’ve been given a second chance here.

“I can’t put into words how grateful I am but I wanted to give back, so to speak, since late last year and so was delighted to be able to meet Alex. We certainly will remain in touch. There’s no doubt about that.”

As published in the Wales Online.

Shared on: www.stemcellworx.com

Saved From Amputation – My Own Stem Cells Rebuilt My Shattered Leg

Sunday, July 13th, 2014

 Clive Randall

•   Clive Randell, 57 injured his leg in a motorcycle accident in 2011

•   His entire life changed from that day forward  

•   He lost his income, his job and his girlfriend  

•   Now, thanks to a new stem cell procedure, he can ride his bike again

•   Adult stem cells from his own bone marrow were blended with gel and this combination then glued the bone. 

•   The results were profound 

Source:   www.dailymail.co.uk

 A pioneering stem cell procedure to repair fractured bones could provide a lifeline for accident victims facing the amputation of a limb.

The development involves harvesting stem cells, a person’s own stem cells.  These ‘master’ cells are able to transform into any kind of body tissue.  They are taken from the patient’s own bone marrow.  In this procedure, they were then blended with a specialty gel and the solution was injected into the damaged bone.

One patient already benefiting is lifelong motorcycle enthusiast Clive Randell who suffered horrific injuries to his left leg when his Harley-Davidson was rammed by a car in 2011.

He suffered multiple open fractures, leaving bone protruding through the skin, and extensive skin loss. Doctors repeatedly told him his leg would have to be amputated.

Today, Clive, 57, is back  on his feet – and, astonishingly, also his bike – thanks to the ground-breaking stem-cell treatment.

He says: ‘I may never dance the tango, but, thanks to Professor Shetty, I will be able to get as near to normal as possible.’

There are 350,000 serious fractures admitted to hospitals in the UK every year.

Five to ten per cent fail to heal, leading to multiple operations, bone-grafting and, if these treatments fail, potentially amputation.  Previously, the lack of blood and DNA in a fractured bone has meant newly introduced cells have no way of ‘signalling’ the damaged cells to regenerate.

This new treatment overcomes this obstacle.

‘These “miracle” cells are abundant in bone marrow, so may be  harvested, concentrated and applied with a collagen ‘scaffold’ into an area of poor healing.’

Bone marrow is drawn from the patient’s pelvis using a hollow needle. This marrow contains a mixture of stem cells, red blood cells and blood-forming cells.

This actual operation is performed under a general anaesthetic.  It takes only 30 minutes and the patient can walk in and then go home on the same day. To date, it has been carried out successfully on six patients in the UK, four in India and twenty in South Korea.

‘These experiments have shown that collagen can trigger the transformation of stem cells into bone forming cells,’ says Professor Anan Shetty, Deputy Director of Minimally Invasive Surgery at Kent’s Canterbury Christ Church University.

‘It’s a win-win situation.’

Clive’s Experience

In the 18 months after his accident,  Clive, a high-altitude window cleaner from Orpington, Kent, had  a cage screwed to his damaged  leg, three bone grafts and a raft of other procedures.

As a result of the accident (for which the driver of the car was  successfully prosecuted) and the  medication prescribed, he lost his job, his girlfriend and most of his money. At one stage he contemplated suicide.

At his wits’ end, Clive – who had never been admitted to hospital in his life – turned to the internet and typed in the search box ‘I want to save my leg’.

He came across Prof Shetty’s name, and says he is still in a state of disbelief over the reversal in his fortunes since having the operation in 2012.

‘Six hours after the operation, Professor Shetty told me to get up and go for a walk,’ he says. ‘After being in and out of hospitals, I really couldn’t believe it.

‘I’d suffered 15 months of being told there was a good chance I was going to lose my leg, yet eight weeks after the procedure I was told to start putting weight on it and to walk as much as I could.

‘It still hurts to walk long distances, but that will improve.

‘My foot is turned out a little bit  to the side and I have a limp, but that’s a small price to pay to keep my leg.

‘My hope is this procedure will eventually be available to everyone, since it can help so many people, particularly the military.

‘The old way of mending broken bones is so painful and stops you getting on with your life.

‘Professor Shetty’s stem cell surgery is quick and almost painless, so it’s important more people hear about it.’