Archive for the ‘Stem Cell Worx’ Category

Stem cells Could Help Stop Arthritis

Monday, September 2nd, 2013

A Cambridgeshire clinic has received approval to use adult stem cells to help repair and regenerate damaged tissues and joints.

The Villar Bajwa Practice at the Spire Cambridge Lea Hospital in New Road, Impington, is the first private hospital in the UK to offer the treatment for the hip – tackling the early stages of arthritis.

It is also one of only a handful of sites to do the same for the knee, in which stem cells are used to create more cartilage, helping to preserve the natural hip and knee joints and delay or prevent the need for bigger operations such as joint replacements.

The operation costs about £3,800 on the NHS and slightly more privately.

Consultant orthopaedic surgeon, Richard Villar, runs the Impington practice with Ali Bajwa.

He said: “One of the Holy Grails of my specialty is to encourage gristle – articular cartilage – to heal.

“Gristle is that shiny, white layer on the end of a bone that most will have seen on a chicken drumstick. In humans, it coats the ball of the hip, and the hip socket but it features in many other joints, too – knees, shoulders, elbows, wrists, ankles, toes and even fingers.

“Sadly, the moment a gristle surface is breached, be that by injury or even simple ageing, if the damage remains untreated it can gradually expand until arthritis intervenes.”

Over the years, surgeons have tried a range of methods to address the problem including microfracture, which involves making a sequence of tiny holes in exposed bone to encourage the release of gristle-forming cells from the bone marrow, but it has had limited success.

Now attention has turned to stem cells, which are capable of converting themselves into different tissue in a process known as differentiation.

Surgeons harvest stem cells from the patient before using key hole surgery in either the hip or knee, preparing the arthritic area, and applying the stem cells, normally in combination with microfracture.

Mr Villar added: “Early results for humans, both in the laboratory and clinical practice, are showing great promise for orthopaedic surgery.”

Reference:  http://www.cambridge-news.co.uk

Growth Factors Are A Must For Stem Cell Activation

Wednesday, August 28th, 2013

A growth factor is a naturally occurring substance capable of stimulating cellular differentiation and proliferation.  In most cases, growth factors are a protein.  Growth factors and adult stem cells go hand in hand.

Once the growth factors bind to the cell-surface receptors a sequence of health promoting events inside the cell begin.  There are a number of different growth factors and they have different roles to perform.  However, to summarize their key role, once the cell communication and signaling is initiated, the growth factors get to work on facilitating their repair and renewal capabilities in a variety of ways ranging from tissue and wound repair, the healing of collagen, development of the central nervous system, and enhancing immune response and metabolic processes.

Here is just a snapshot of some important growth factors:

  • Epidermal growth factor (EGF)
  • Granulocyte colony-stimulating factor (G-CSF)
  • Fibroblast growth factor (FGF)
  • Insulin-like growth factor (IGF-1)
  • Insulin-like growth factor (IGF-2)
  • Nerve growth factor (NGF) and other neurotrophins
  • Platelet-derived growth factor (PDGF)
  • Transforming growth factor alpha(TGF-α)
  • Transforming growth factor beta(TGF-β)
  • Platelet-derived growth factor (PDGF)
  • IL-1- Cofactor for IL-3 and IL-6 [Activates T cells]
  • IL-6- Stimulates Ig synthesis [Growth factor for plasma cells]
  • Vascular endothelial growth factor (VEGF)

Here Doctor Hauser talks about the important role of growth factors.