Archive for the ‘mesenchymal stem cells’ Category

Adult Mesenchymal Stem Cells (MSCs) May Extend Lifespan

Saturday, August 29th, 2015

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SEOUL, South Korea, Aug. 28, 2015

• Joint research by Prof. Kim from Chungbuk National University and Dr. Ra from Biostar
• Published in ‘Stem Cells Translational Medicine’ (IF 5.7)
• Confirmed 30% increase of lifespan through multiple IV administration of Adipose-derived MSCs
• Increase in cognitive function, physical vitality, and life expectancy found

Researchers in Korea have determined the possibility that adult mesenchymal stem cells (MSCs) may extend healthy life and lifespan by intravenous injections.

Professor Kim from Chungbuk National University and Dr. Ra from Biostar, as a joint research team, announced that the discovery was published in International Journal of Medicine, ‘Stem Cells Translation Medicine’ (IF 5.7) on August 27, 2015.

The study, which is selected as the featured paper, intends to introduce the research to the public. As a result of monthly intravenous injections of 1 million human adipose-derived stem cells into 10-month old rats until their death, cognitive function such as learning and memory improved and lifespan was extended by 31.3% through regeneration of blood vessels in the brain and muscles.

Through the research, intravenously injected MSCs were found to move to the brain and differentiate into brain cells which increase cognitive function and physical vitality by activating cholinergic and dopaminergic nerves. Especially, by removing chemokine called CCL11 which prevents regeneration of brain tissues, MSCs induce regeneration of stem cells called Nestin-positive cells in animal brains, which eventually regenerated brain cells.

Moreover, the research team determined that MSCs derived from amniotic placenta may help to increase life expectancy by 23.4% by differentiation and regeneration of brain cells in the same mechanism as that of adipose-derived mesenchymal stem cells. These results prove that multiple intravenous injections of adult stem cells extend lifespan. With little immune rejection response, autologous or allogenic stem cells are expected to form an anti-aging market of a trillion Korean Won that could extend many years into the future.

Dr.Ra, a co-corresponding author of this study and CTO of R Bio and R-Japan, explained, “For the next three years, we will be researching with global aging researchers on new stem cell culture methods using 10 species of representative aging animal models to increase life expectancy and health span by at least 50%. We will try our best to commercialize its use within five years.”

SOURCE: Stem Cells Translational Medicine
http://www.stemcellsportal.com/stem-cell-treatments-help-rats-live-longer-healthier-lives

Tags: mesenchymal stem cell supplement, MSC supplement
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Adult Stem Cell Therapy for Spinal Cord Injuries

Friday, January 10th, 2014

SAPPORO (Jiji Press)—Sapporo Medical University said Friday, January 10^th, 2014 it will start Japan’s first clinical trial using stem cells for nerve regeneration in patients with spinal cord injuries.

The team will collect bone marrow fluid from patients who injured their spinal cords within the previous two weeks, take mesenchymal stem cells (these being adult stem cells) that develop into nerves out of the fluid, and cultivate them in large quantities to make cell preparation for intravenous injection into the patients.

The chances of rejection are low because patients’ own cells will be used and the physical strain from intravenous injection is limited, according to the team.

Examinees in the clinical trial must be aged between 20 and 64, and meet such conditions as having suffered their main injury in their cervical cord.

About 5,000 people in Japan suffer spinal cord injuries each year, which often causes loss of motor functions or sensory paralysis, but there is no effective therapy at present, according to Yamashita.

If nerves are regenerated through the stem cell-based therapy, patients may become able to move their hands or legs again.

Yamashita and Honmo told a press conference that the team has confirmed lasting effects of the method in basic research using mice.

In the coming trial, the cell preparation made from the mesenchymal stem cells will be injected into patients within 54 days of their spinal cord injury, they said.

Yamashita said the team hopes to finish the clinical trial as early as possible, but added that he cannot say at the moment when the therapy will be put into practical use.

Tags: spinal cord clinical injury, spinal cord injury clinical trial, stem cells for spinal cord injuries
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